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VU0810464
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VU0810464图片
规格:98%
分子量:349.83
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
VU0810464 是有效的,选择性的非尿素蛋白门控的内向整流钾通道 (GIRK, Kir3) 激活剂。 VU0810464 对神经元 GIRK1/2 (EC50=165 nM) 和 GIRK1/4 (EC50=720 nM) 神经通道具有纳摩尔效价,并且具有脑部渗透性。
货号:ajcx16670
CAS:2126040-21-7
分子式:C18H21ClFN3O
分子量:349.83
溶解度:DMSO: ≥ 250 mg/mL (714.63 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC50=165 nM) and GIRK1/4 (EC50=720 nM) channels with improved brain penetration[1][2].


[1]. Vo BN, et al. VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir 3 channels and reduces stress-induced hyperthermia in mice.Br J Pharmacol. 2019 Jul;176(13):2238-2249. [2]. Wieting JM,et al. Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators.ACS Chem Neurosci. 2017 Sep 20;8(9):1873-1879.