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GSK2798745
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK2798745图片
规格:98%
分子量:460.53
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
GSK2798745 是一流的,高效的,选择性的且具有口服活性的 瞬时受体电位香草酸 4 (TRPV4) 离子通道阻断剂,对于 hTRPV4 和 rTRPV4 的 IC50 值分别为 1.8 和 1.6 nM。GSK2798745 用于治疗与充血性心力衰竭相关的肺水肿的研究。
货号:ajcx16534
CAS:1419609-94-1
分子式:C25H28N6O3
分子量:460.53
溶解度:DMSO: 250 mg/mL (542.85 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure[1][2].


[1]. Goyal N, et al. Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects. Am J Cardiovasc Drugs. 2019 Jun;19(3):335-342. [2]. Brooks CA, et al. Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4). ACS Med Chem Lett. 2019 Jul 15;10(8):1228-1233.