Ethyl Caffeate 是一种从 Bidens pilosa 分离的天然酚类化合物。Ethyl Caffeate 在体外或在小鼠皮肤中抑制 NF-κB 活化及其下游炎症介质，诱导型一氧化氮合酶 (iNOS)，环氧合酶 2 (COX-2) 和前列腺素 E2 (PGE2)。
货号:ajcx15158
CAS:102-37-4
分子式:C11H12O4
分子量：208.21
溶解度:DMSO: 250 mg/mL (1200.71 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin[1].

Ethyl Caffeate markedly suppresses the lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 of 5.5 μg/ml[1].

[1]. Chiang YM, et al. Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. Br J Pharmacol. 2005 Oct;146(3):352-63.