AZD-5991S-enantiomer是AZD-5991的低活性S型对映体。AZD-5991S-enantiomer是一种Mcl-1抑制剂，FRET实验检测的IC50为6.3μM，SPR实验检测的Kd为0.98μM。
货号:ajcx12934
CAS:2143061-82-7
分子式:C35H34ClN5O3S2
分子量：672.26
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.

[1]. Tron AE, et al. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun. 2018 Dec 17;9(1):5341.