GOAT-IN-1是胃促生长素O-酰基转移酶(GOAT)的抑制剂，可用于预防或治疗肥胖、糖尿病、高脂血症、非酒精性脂肪肝、脂肪性肝炎、骨骼肌减少症、食欲控制、酒精/麻醉性依赖、阿尔茨海默症、帕金森、脑血管疾病与老年痴呆、脑卒中、脑梗死、心血管疾病、一些肿瘤等。
货号:ajcx12480
CAS:1452473-54-9
分子式:C18H13ClF3NO3S
分子量：415.81
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer's disease, Parkinson's disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.

The inhibitory activity of GOAT-IN-1 (Example 16) for human GOAT is 101% with the concentration of 10 μM[1].

[1]. WO 2013125732.