LY2794193是一种高效的选择性mGlu3受体激动剂(hmGlu3Ki=0.927nM，EC50=0.47nM;hmGlu2Ki=412nM，EC50=47.5nM)。
货号:ajcx12474
CAS:2173037-97-1
分子式:C16H18N2O6
分子量：334.32
溶解度:H2O : 2 mg/mL (5.98 mM; ultrasonic and adjust pH to 14 with NaOH)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM，EC50=0.47 nM; hmGlu2 Ki=412 nM，EC50=47.5 nM)[1].

[1]. Monn JA, et al. Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist. J Med Chem. 2018 Mar 22;61(6):2303-2328.