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ACY-957
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACY-957图片
规格:98%
分子量:429.54
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
ACY-957是一种选择性的HDAC1和HDAC2抑制剂,对HDAC1/2/3的IC50值分别为7nM,18nM和1300nM,对HDAC4/5/6/7/8/9无作用。
货号:ajcx12400
CAS:1609389-52-7
分子式:C24H23N5OS
分子量:429.54
溶解度:DMSO : 83.33 mg/mL (194.00 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.

ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 has an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors[1].


[1]. Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11(4):e0153767.