DS-1971a 是一种有效的、选择性的、具有口服活性的 NaV1.7 抑制剂，对 hNaV1.7 和 mNaV1.7 的 IC50 分别为 22.8 和 59.4 nM。
货号:ajcx11568
CAS:1799681-85-8,1450595-86-4
分子式:C??H??ClFN?O?S
分子量：465.93
溶解度:100 mg/mL in DMSO (214.62 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DS-1971a is a potent, selective, and orally active?NaV1.7?inhibitor, with?IC₅₀s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects[1]

DS-1971a exhibits a favorable toxicological profile[1]

DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice[1]

参考文献:
[1]. Shinozuka T, et al. Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor [published online ahead of print, 2020 May 26]. J Med Chem. 2020;10.1021/acs.jmedchem.0c00259.