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PSB 1114
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PSB 1114图片
包装:1mg
规格:98%
市场价:4394元
分子量:622.14

产品介绍
P2Y2 receptor agonist
货号:ajcx11352
CAS:
分子式:C10H11F2N2Na4O13P3S
分子量:622.14
溶解度:<10mm in h2o
纯度:98%
存储:Store at -20°C
库存:现货

Background:

PSB 1114 is a potent and selective agonist of P2Y2 receptor with EC50 value of 0.134 μM [1].

P2Y2 receptor is a purinergic G protein-coupled receptor and is activated by ATP and UTP. P2Y2 receptor is a potential target for treatment of cystic fibrosis.

PSB 1114 is a potent and selective P2Y2 receptor agonist. PSB 1114 activated P2Y2, P2Y4 and P2Y6 with EC50 values of 0.134, 9.3 and 7.0 μM respectively and exhibited >60-fold selectivity versus P2Y6 and P2Y4 receptors [1].

参考文献:
[1].  El-Tayeb A, Qi A, Nicholas RA, et al. Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem, 2011, 54(8): 2878-2890.