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PD-1-IN-24
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PD-1-IN-24图片
规格:98%
分子量:469.5
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
PD-1-IN-24 (compound 1) 是具有口服活性的 PD-1 的抑制剂。
货号:ajcx35838
CAS:2360909-50-6
分子式:C27H26F3NO3
分子量:469.5
溶解度:DMSO : 100 mg/mL (212.99 mM; ultrasonic and warming and heat to 60°C)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor[1].

PD-1-IN-24 (compound 1, 15mg/kg, PO, BID) exhibits TGI(%) of 19.96% in the subcutaneous 4T1 murine breast cancer model in BALB/c mice[1].PD-1-IN-24 (compound 1, 15mg/kg, PO, BID) dose-dependently inhibits tumor growth in the Bl6F10 models with TGI% of 35.59% (30 mg/kg), 38.87% (60 mg/kg) and 47.35% (120 mg/kg), respectively[1].

[1]. Wang, Yuguang, et al. Combination of small molecule inhibitor of the PD-1/PD-L1 interaction and anti-PD-1 antibody for treatment of cancer. Patent WO 2021052386.