PX20606, formerly known as PX-102, is a FXR agonist. PX20606 induces high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice. PX20606 demonstrated potent plasma cholesterol-lowering activity that affected all lipoprotein species. References: Deuschle U, Birkel M, Hambruch E, Hornberger M, Kinzel O, Perovic-Ottstadt S, Schulz A, Hahn U, Burnet M, Kremoser C. The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein. Int J Cancer. 2015 Jun 1;136(11):2693-704. doi: 10.1002/ijc.29312. Epub 2014 Nov 13. PubMed PMID: 25363753.

纯度：≥98%

CAS：1268244-85-4