Biotin-PEG12-NHSester是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
货号:ajcx32464
CAS:1934296-88-4
分子式:C41H72N4O18S
分子量：941.09
溶解度:DMSO: 100 mg/mL (106.26 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Biotin-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562