BAY73-1449是一种选择性前列环素受体(prostacyclinreceptor,IP)的拮抗剂，在人HEL细胞和大鼠DRG的cAMP分析中具有很高的效价(IC50值小于0.1nM)。BAY73-1449可用于降血压的研究。
货号:ajcx32048
CAS:693790-96-4
分子式:C26H23N3O3
分子量：425.48
溶解度:DMSO: 250 mg/mL (587.57 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure[1].

BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats[1].BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats[1].BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats[1]. Animal Model: Male Wistar rats (250-350 g) are ligated portal vein[1]

[1]. Bexis S, et, al. Vascular actions of the prostacyclin receptor antagonist BAY 73-1449 in the portal hypertensive rat. Eur J Pharmacol. 2008 Aug 20;590(1-3):322-6.