您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > XZ739
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
XZ739
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
XZ739图片
规格:98%
分子量:1349.99
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
XZ739是一种基于CRBN的PROTACBCL-XL降解剂,作用于MOLT-4细胞,处理16小时后,DC50值为2.5nM。XZ739还通过caspase介导的凋亡(apoptosis)诱导细胞死亡。
货号:ajcx31672
CAS:2365172-19-4
分子式:C65H76ClF3N8O12S3
分子量:1349.99
溶解度:DMSO: 20 mg/mL (14.81 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].

XZ739 (0.001-10 μM; 48 hours) potently reduces the viability of T-ALL MOLT-4, B-ALL RS4; 11, SCLC NCI-H146 cells, and platelets after 48 h treatment with IC50s of 10.1, 41.8, 25.3, and 1217 nM, respectively. XZ739 has >100-fold selectivity for MOLT-4 cells over human platelets[1].XZ739 (1.2-300 nM; 16 hours) induces BCL-XL degradation in MOLT-4 cells[1]. The BCL-XL degradation induced by XZ739 in MOLT-4 is rapid, starting within 2 h; and 8 h after XZ739 treatment, more than 96% of the BCL-XL is degraded with 100 nM of XZ739[1]. Cell Viability Assay[1] Cell Line: Human platelets and MOLT-4 cells


[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.