PROTACRIPKdegrader-6(example1)是一种PROTAC类的有效RIPK降解剂。
货号:ajcx31354
CAS:2089205-64-9
分子式:C43H48N6O11S2
分子量：889
溶解度:DMSO: 100 mg/mL (112.49 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1].

PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation[1].

[1]. John David Harlin, et al. Compounds for the modulation of rip2 kinase activity. WO2017046036A1.