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LSN3106729 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LSN3106729 hydrochloride图片
规格:98%
分子量:531
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
LSN3106729hydrochloride,Abemaciclib的代谢物,是一种具有抗肿瘤活性的CDK抑制剂。LSN3106729hydrochloride和CRBN配体可用于设计PROTACCDK4/6降解剂。
货号:ajcx30954
CAS:N/A
分子式:C25H29ClF2N8O
分子量:531
溶解度:DMSO: 125 mg/mL (235.40 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

LSN3106729 hydrochloride, the metabolite of Abemaciclib , is a CDK inhibitor with antitumor activity. LSN3106729 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1].


[1]. Edward S. Kim, et al. Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non-Small Cell Lung Cancer: A Phase Ib Study. [2]. Nathanael Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use. WO2017185031A1.