您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Maleimido-tri(ethylene glycol)-propionic acid
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Maleimido-tri(ethylene glycol)-propionic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Maleimido-tri(ethylene glycol)-propionic acid图片
规格:98%
分子量:301.29
包装与价格:
包装价格(元)
100mg电议
250mg电议

产品介绍
Maleimido-tri(ethylene glycol)-propionic acid 是一种可切割的 ADC linker,用于合成抗体-药物偶联物 (ADCs)。Maleimido-tri(ethylene glycol)-propionic acid 用于 neolymphostin 为基础的 ADC 前体的制备,用于位点特异性半胱氨酸突变体曲妥珠单抗- A114C 的偶联。
货号:ajcx29484
CAS:518044-40-1
分子式:C13H19NO7
分子量:301.29
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1].

Mal-PEG3-C2-acid can be used to synthesis linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7[1].ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively[1].ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 195 and 202 nM, respectively[1].ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 286 and 274 nM, respectively[1].


[1]. Zhou D,et al. Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.Bioorg Med Chem Lett. 2019 Apr 1;29(7):943-947.