CTTHWGFTLC,CYCLICTFA是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为8μM。
货号:ajcx29242
CAS:N/A
分子式:C54H72F3N13O16S2
分子量：1280.35
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM[1].

CTTHWGFTLC, CYCLIC TFA inhibits endothelial and tumor cell migration in vitro[1].

CTTHWGFTLC, CYCLIC TFA inhibits tumor progression in vivo, in mouse models[1].

[1]. Medina OP, et al. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro. Cancer Res. 2001 May 15;61(10):3978-85.