An internal standard for the quantification of (R,S)-anatabine
货号:ajcx28544
CAS:1020719-11-2
分子式:C10H8D4N2
分子量：164.2
溶解度:Chloroform: soluble,Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(R,S)-Anatabine-d₄is intended for use as an internal standard for the quantification of (R,S)-anatabine by GC- or LC-MS. (R,S)-Anatabine is an alkaloid that has been found as a minor component in tobacco (Nicotiana).¹It is an agonist of α4β2 and α6/α3β2β4 subunit-containing nicotinic acetylcholine receptors (nAChRs; EC₅₀s = 6.1 and 3.6 µM, respectively). It is selective for α4β2 and α6/α3β2β4 subunit-containing nAChRs over α3β4 subunit-containing nAChRs or α7 nAChRs (EC₅₀s = 70.6 and 158.5 µM, respectively).²(R,S)-Anatabine stimulates dopamine, but not norepinephrine, release from isolated rat brain synaptosomes (EC₅₀s = 1.76 and >100 µM, respectively). It increases the time spent at the top of the tank in a novel tank test, indicating anxiolytic-like activity, in zebrafish when used at a concentration of 10 mg/L. (R,S)-Anatabine (0.05 mg/ml in the drinking water) decreases disease severity in a mouse model of moderate, but not low or severe, experimental autoimmune thyroiditis induced by immunization with thyroglobulin, complete Freund's adjuvant (CFA), andM. tuberculosis.³It decreases food and nicotine self-administration in monkeys (ED₅₀s = 2.085 and 0.854 mg/kg, respectively).⁴(R,S)-Anatabine has been used as a biomarker of tobacco use.^5,6

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