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COTC
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
COTC图片
包装:1mg
规格:98%
市场价:11319元
分子量:242.2

产品介绍
A bacterial metabolite with anticancer activity
货号:ajcx28226
CAS:57449-30-6
分子式:C11H14O6
分子量:242.2
溶解度:DMSO: soluble,Methanol: soluble,Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

COTC is a bacterial metabolite that has been found inS. griseosporeusand has anticancer activity.1It inhibits glyoxalase in the presence of glutathione (GSH) in a concentration- and time-dependent manner. COTC inhibits the proliferation of HeLa cells (IC50= 18 µg/ml), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.

1.Takeuchi, T., Chimura, H., Hamada, M., et al.A glyoxalase I inhibitor of a new structural type produced by StreptomycesJ. Antibiot. (Tokyo)28(1)737-742(1975)