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ST 045849
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ST 045849图片
规格:98%
分子量:446.99
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
O-GlcNAc transferase (OGT) inhibitor
货号:ajcx27814
CAS:442665-87-4
分子式:C23H27ClN2O3S
分子量:446.99
溶解度:44.7mg/mL in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

O-GlcNAc transferase (OGT) inhibitor (IC50 = 53 μM). Reduces proliferation and viability of prostate cancer cells in vitro. Depletes intracellular alanine and decreases glucose consumption by cancer cells. Decreases markers of ER stress and apoptosis in pregnant diabetic mice and reduces neural tube defects in embryos from diabetic mice.


Itkonen et al (2016) Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. Oncotarget 7 12464 PMID:26824323 |Kim et al (2017) Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy. Sci.Rep. 7 11107 PMID:28894244 |Kim et al (2014) Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors. Bioconjug.Chem. 25 1025 PMID:24866374