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WAY 181187 oxalate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WAY 181187 oxalate图片
规格:98%
分子量:470.91
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
WAY-181187 (SAX-187) oxalate 是一种有效的选择性全 5-HT6 受体激动剂,Ki 为 2.2 nM,EC50 为 6.6 nM。
货号:ajcx27136
CAS:1883548-85-3
分子式:C15H13ClN4O2S2.C2H2O4
分子量:470.91
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

High affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.


Brouard et al (2015) Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 6 1241 PMID:25837696 |Cole et al (2007) Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist. J.Med.Chem. 50 5535 PMID:17948978