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Hygromycin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hygromycin A图片
规格:98%
分子量:511.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An antibiotic
货号:ajcx26318
CAS:6379-56-2
分子式:C23H29NO12
分子量:511.5
溶解度:DMF: 16 mg/mL,DMSO: 10 mg/mL,Ethanol: 12 mg/mL,PBS (pH 7.2): 10 mg/mL
纯度:98%
存储:Store at -20°C
库存:现货

Background:


Hygromycin A is an antibiotic originally isolated fromS. hygroscopicus.1It is active against numerous spirochete bacteria, includingT. pallidum,L. biflexa, and four strains ofB. burgdorferi(MICs = 0.03-4 µg/ml for all). Hygromycin A binds to the peptidyl transferase center (PTC) in the 70S ribosomal subunit to inhibit protein synthesis. It completely eliminates bacterial infection in skin biopsies fromB. burgdorferi-infected mice in a model of acute Lyme disease when administered at doses ranging from 50 to 250 mg/kg twice per day.


1.Leimer, N., Wu, X., Imai, Y., et al.A selective antibiotic for Lyme diseaseCell184(21)5405-5418.e5416(2021)