规格: | 98% |
分子量: | 511.5 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Background:
Hygromycin A is an antibiotic originally isolated fromS. hygroscopicus.1It is active against numerous spirochete bacteria, includingT. pallidum,L. biflexa, and four strains ofB. burgdorferi(MICs = 0.03-4 µg/ml for all). Hygromycin A binds to the peptidyl transferase center (PTC) in the 70S ribosomal subunit to inhibit protein synthesis. It completely eliminates bacterial infection in skin biopsies fromB. burgdorferi-infected mice in a model of acute Lyme disease when administered at doses ranging from 50 to 250 mg/kg twice per day.
1.Leimer, N., Wu, X., Imai, Y., et al.A selective antibiotic for Lyme diseaseCell184(21)5405-5418.e5416(2021)