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BMS 270394
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS 270394图片
规格:98%
分子量:399.5
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
A RARγ agonist
货号:ajcx26244
CAS:262433-54-5
分子式:C23H26FNO4
分子量:399.5
溶解度:DMSO: 20 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:


BMS 270394 is an agonist of retinoic acid receptor γ (RARγ; EC50= 30 nM in a transactivation assay) and the active enantiomer of BMS 189961 .1It is selective for RARγ over RARβ (EC50= 400 nM) and is inactive at RARα. BMS 270394 synergizes with paclitaxel to inhibit the growth of MCF-7 breast and OVCAR-3 ovarian cancer, as well as SqCC/Y1 head and neck squamous cell carcinoma, cells.2


1.Klaholz, B.P., Mitschler, A., Belema, M., et al.Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγProc. Natl. Acad. Sci. USA97(12)6322-6327(2000) 2.Vivat-Hannah, V., You, D., Rizzo, C., et al.Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel)Cancer Res.61(24)8703-8711(2001)