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Nicotinamide-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nicotinamide-d4图片
规格:98%
分子量:126.2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
烟酰胺-d4 (Niacinamide-d4) 是氘标记的烟酰胺。
货号:ajcx25504
CAS:347841-88-7
分子式:C6H2D4N2O
分子量:126.2
溶解度:DMF: 15 mg/ml,DMSO: 15 mg/ml,Ethanol: 2.5 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Nicotinamide-d4is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesizedin vivoor obtained through the diet.1It is a precursor in the synthesis of the metabolic cofactor NAD+and an inhibitor of sirtuin 1 (SIRT1; IC50=<50 µm).2Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes.3Nicotinamide (40 µM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC.4Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing.5,6,7


1.Li, F., Chong, Z.Z., and Maiese, K.Cell life versus cell longevity: The mysteries surrounding the NAD+ precursor nicotinamideCurr. Med. Chem.13(8)883-895(2006) 2.Bitterman, K.J., Anderson, R.M., Cohen, H.Y., et al.Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1J. Biol. Chem.277(47)45099-45107(2002) 3.Tanno, O., Ota, Y., Kitamura, N., et al.Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrierBr. J. Dermatol.143(3)524-531(2000) 4.Park, S.Y., Lee, K.B., Lee, M.-J., et al.Nicotinamide inhibits the early stage of carcinogen-induced hepatocarcinogenesis in mice and suppresses human hepatocellular carcinoma cell growthJ. Cell. Physiol.227(3)899-908(2012) 5.Lukasova, M., Hanson, J., Tunaru, S., et al.Nicotinic acid (niacin): New lipid-independent mechanisms of action and therapeutic potentialsTrends Pharmacol. Sci.32(12)700-707(2011) 6.Bodor, E.T., and Offermanns, S.Nicotinic acid: An old drug with a promising futureBr. J. Pharmacol.153(Suppl 1)S68-S75(2008) 7.Haining, C.G.Effects of anti-rheumatic compounds and pyridine derivatives on the cutaneous response to thurfyl nicotinate in the guinea-pigBr. J. Pharmacol. Chemother.21(1)104-112(1963)