A synthetic peptide fragment of galanin and an agonist of the GAL2 receptor
货号:ajcx25286
CAS:N/A
分子式:C54H81N13O14·XCF3COOH
分子量：1136.3
溶解度:DMF: 5 mg/ml,DMSO: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL₂) receptor (EC₅₀= 9.32 nM in a fluorescence imaging plate reader assay).¹It selectively binds to the GAL₂receptor (IC₅₀= 1.76 nM for the rat receptor) over the GAL₁receptor (IC₅₀= 879 nM for the human receptor) but does also bind to the GAL₃receptor (K_i= 271 nM for the rat receptor).^1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.³It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.¹

1.Liu, H.-X., Brumovsky, P., Schmidt, R., et al.Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptorsProc. Natl. Acad. Sci. USA98(17)9960-9964(2001) 2.Lu, X., LundstrÖm, L., and Bartfai, T.Galanin (2-11) binds to GalR3 in transfected cell lines: Limitations for pharmacological definition of receptor subtypesNeuropeptides39(3)165-167(2005) 3.Kuteeva, E., Wardi, T., LundstrÖm, L., et al.Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body levelNeuropsychopharmacology33(11)2573-2585(2008)