A STAT3 inhibitor
货号:ajcx25256
CAS:1245814-52-1
分子式:C11H6F3N3O3S
分子量：317.2
溶解度:DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CAY10784 is a STAT3 inhibitor (IC₅₀= 0.74 µM in a reporter assay) and a derivative of WP1066 .¹It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC₅₀s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 µM, respectively) but not PC3 or HT-29 cancer cells (IC₅₀s = >10 µM for both). CAY10784 is also active againstH. pyloriandC. jejuni(MICs = 1.6 and 4.7 µM, respectively).²

1.LÜ, Z., Li, X., Li, K., et al.Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway inhibitorsACS Med. Chem. Lett.(2021) 2.Ballard, T.E., Wang, X., Olekhnovich, I., et al.Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: Identification of selective and broad spectrum activityChemMedChem6(2)362-377(2011)