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Hydroxy Celecoxib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hydroxy Celecoxib图片
规格:98%
分子量:397.4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An inactive metabolite of celecoxib
货号:ajcx25238
CAS:170571-00-3
分子式:C17H14F3N3O3S
分子量:397.4
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Hydroxy celecoxib is an inactive metabolite of celecoxib .1It is formed from celecoxib by the cytochrome P450 (CYP) isoforms CYP2C9, CYP3A4, and CYP2D6 in human liver microsomes.2


1.Penning, T.D., Talley, J.J., Bertenshaw, S.R., et al.Synthesis and biological evaluation fo the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib)J. Med. Chem.40(9)1347-1365(1997) 2.Siu, Y.A., Hao, M.-H., Dixit, V., et al.Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variantsDrug Metab. Pharmacokinet.33(5)219-227(2018)