A bacterial metabolite with diverse biological activities
货号:ajcx25066
CAS:150151-88-5
分子式:C29H28O5
分子量：456.5
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.^1,2It inhibits glutathione S-transferase (GST; IC₅₀= 24 µg/ml for the rat liver enzyme).²Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC₅₀= 10 µg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner.

1.Xu, Z., Schenk, A., and Hertweck, C.Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybridsJ. Am. Chem. Soc.129(18)6022-6030(2007) 2.Aoyama, T., Kojima, F., Yamazaki, T., et al.Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activitiesJ. Antibiot. (Tokyo)46(5)712-718(1993)