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Fenspiride-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fenspiride-d5图片
规格:98%
分子量:265.4
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of fenspiride
货号:ajcx24724
CAS:1246911-67-0
分子式:C15H15D5N2O2
分子量:265.4
溶解度:DMSO: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Fenspiride-d5is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1receptors and a non-steroidal anti-inflammatory drug (NSAID).1,2It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from patients with lung cancer).3It is selective for these phosphodiesterases over PDE1 and PDE2, where it provides less than 25% inhibition. Fenspiride potentiates the airway relaxant effects of isoproterenol and sodium nitroprusside indicating an effect on cAMP and cGMP phosphodiesterases, respectively. Aerosolized fenspiride (1 mg/ml) reverses bronchoconstriction induced by capsaicin and, when used at aerosolized concentrations ranging from 1-10 mg/ml, reduces cough induced by citric acid in a guinea pig model of cough.2


1.Rognoni, F., Marchini, F., Piacenza, G., et al.Effect of 8-N-phenethyl-1-oxa-2-oxo-3,8-diazaspiro(4,5)decane hydrochloride (decaspiride) on histamine receptorsBoll. Chim. Farm.117(7)397-401(1978) 2.Laude, E.A., Bee, D., Crambes, O., et al.Antitussive and antibronchoconstriction actions of fenspiride in guinea-pigsEur. Respir. J.8(10)1699-1704(1995) 3.Cortijo, J., Naline, E., Ortiz, J.L., et al.Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: Functional and biochemical studyEur. J. Pharmacol.341(1)79-86(1998)