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Trimethoprim-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trimethoprim-d3图片
规格:98%
分子量:293.3
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
Trimethoprim-D3 是氘标记的 Trimethoprim。
货号:ajcx23662
CAS:1189923-38-3
分子式:C14H15D3N4O3
分子量:293.3
溶解度:DMSO: Slightly Soluble,Methanol: Slightly Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Trimethoprim-d3is intended for use as an internal standard for the quantification of trimethoprim by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid.1,2Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).2Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.


1.Lam, T., Hilgers, M.T., Cunningham, M.L., et al.Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolinesJ. Med. Chem.57(3)651-668(2014) 2.Schweitzer, B.I., Dicker, A.P., and Bertino, J.R.Dihydrofolate reductase as a therapeutic targetFASEB J.4(8)2441-2452(1990)