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PtdIns-(3,4,5)-P3-fluorescein(triethylammonium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PtdIns-(3,4,5)-P3-fluorescein(triethylammonium salt)图片
规格:98%
分子量:1908.2
包装与价格:
包装价格(元)
10ug电议
25ug电议
50ug电议
100ug电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx23370
CAS:N/A
分子式:C46H54NO28P4.7C6H16N
分子量:1908.2
溶解度:Water: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

The phosphatidylinositols (PtdIns) phosphates represent a small precentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2PtdIns-(4,5)-P2can be phosphorylated by phosphatidylinositol (PI)-3-kinase to make PtdIns-(3,4,5)-P3, which initiates an intricate signaling cascade that has been implicated in cancer.3PtdIns-(3,4,5)-P3fluorescein is a fluorescent probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.


1.Exton, J.H.Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteinsAnnu. Rev. Pharmacol. Toxicol.36481-509(1996) 2.Majerus, P.W.Inositol phosphate biochemistryAnnu. Rev. Biochem.61225-250(1992) 3.Vivanco, I., and Sawyers, C.L.The phosphatidylinositol 3-kinase-AKT pathway in human cancerNature Reviews.Cancer2489-501(2002)