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N&epsilon-(1-Carboxymethyl)-L-lysine-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N&epsilon-(1-Carboxymethyl)-L-lysine-d3图片
规格:98%
分子量:207.2
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx23158
CAS:N/A
分子式:C8H13D3N2O4
分子量:207.2
溶解度:PBS (pH 7.2): 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Nε-(1-Carboxymethyl)-L-lysine-d3(CML-d3) is intended for use as an internal standard for the quantification of CML by GC- or LC-MS. CML is an advanced glycation end product (AGE), produced by the oxidative modification of glycated proteins during oxidative stress.1,2,3Levels of CML increase with aging and during diabetes, cancer, vascular disease, and other pathologies marked by oxidative stress.1,4,5CML activates the membrane-bound receptor for AGEs (RAGE), triggering signaling through MAPKs and NF-κB, whereas truncation of RAGE produces a soluble protein that binds CML and reduces signaling.6,7


1.Requena, J.R., Ahemd, M.U., Fountain, C.W., et al.Carboxymethylethanolamine, a biomarker of phospholipid modification during the maillard reaction in vivoThe Journal of Biological Chemisty272(28)17473-17479(1997) 2.Ahmed, M.U., Brinkmann, F.E., Degenhardt, T.P., et al.Nε-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteinsBiochem. J.324(Pt 2)565-570(1997) 3.Schleicher, E.D., Wagner, E., and Nerlich, A.G.Increased accumulation of the glycoxidation product Nε-(carboxymethyl)lysine in human tissues in diabetes and agingJournal of Clinical Investigation99(3)457-468(1997) 4.Campbell, D.J., Somaratne, J.B., Jenkins, A.J., et al.Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery diseaseCardiovascular Diabetology101-14(2011) 5.Brouwers, O., de Vos-Houben, J.M.J., Niessen, P.M.G., et al.Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpressionInternational Journal of Molecular Sciences14(8)15724-15739(2013) 6.Schmidt, A.M., Yan, S.D., Yan, S.F., et al.The biology of the receptor for advanced glycation end products and its ligandsBiochimica et Biophysica Acta1498(2-3)99-111(2000) 7.Moy, K.A., Jiao, L., Freedman, N.D., et al.Soluble receptor for advanced glycation end products and risk of liver cancerHepatology57(6)2338-2345(2013)