您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > N-Arachidonoyl Taurine-d4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
N-Arachidonoyl Taurine-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Arachidonoyl Taurine-d4图片
规格:98%
分子量:415.6
包装与价格:
包装价格(元)
100ug电议
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx23064
CAS:N/A
分子式:C22H33D4NO4S
分子量:415.6
溶解度:DMF: 10 mg/mL,DMSO: 20 mg/mL,PBS (pH 7.2): 1.5 mg/mL
纯度:98%
存储:Store at -20°C
库存:现货

Background:

N-Arachidonoyl taurine-d4is intended for use as an internal standard for the quantification of N-arachidonoyl taurine by GC- or LC-MS. N-Arachidonoyl taurine is an arachidonoyl amino acid.1It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages.2N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 µM, respectively).1It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 µM and increases insulin secretion from 832/13 INS-1 pancreatic β-cells.3The levels of N-arachidonoyl taurine are changed in mouse brain following administration of δ9-tetrahydrocannabinol (δ9-THC).4


1.Saghatelian, A., McKinney, M.K., Bandell, M., et al.A FAAH-regulated class of N-acyl taurines that activates TRP ion channelsBiochemistry45(30)9007-9015(2006) 2.Turman, M.V., Kingsley, P.J., Rouzer, C.A., et al.Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurineBiochemistry47(12)3917-3925(2008) 3.Waluk, D.P., Vielfort, K., Derakhshan, S., et al.N-Acyl taurines trigger insulin secretion by increasing calcium flux in pancreatic β-cellsBiochem. Biophys. Res. Commun.430(1)54-59(2013) 4.Leishman, E., Murphy, M., Mackie, K., et al.δ9-Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adultBiochim. Biophys. Acta. Mol. Cell Biol. Lipids1863(5)479-492(2018)