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Labetalol-d5(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Labetalol-d5(hydrochloride)图片
包装:1mg
规格:98%
市场价:5111元
分子量:369.9

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22778
CAS:N/A
分子式:C19H19D5N2O3.HCl
分子量:369.9
溶解度:DMSO: Soluble,Methanol: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Labetalol-d5is intended for use as an internal standard for the quantification of labetalol by GC- or LC-MS. Labetalol is an adrenergic receptor (AR) antagonist.1It inhibits agonist-induced contraction of rabbit aortic strips, decreases in contractile force in isolated guinea pig atria, and vasorelaxation in isolated guinea pig tracheal strips (pA2s = 6.99, 7.68, and 7.54, respectively), tissues that endogenously express high levels of α-, β1-, and β2-ARs, respectively. Labetalol (2.5-25 mg/kg) reduces blood pressure in spontaneously hypertensive rats. It reduces blood pressure in DOC-salt rats, two-kidney Goldblatt rats, and one-kidney dogs. Labetalol (5 mg/kg) reduces infarct size in a dog model of myocardial infarction induced by occlusion of the left anterior descending artery. Topical administration of labetalol (0.25-1% v/v) reduces intraocular pressure in rabbits. Formulations containing labetalol have been used in the treatment of hypertension.


1.Baum, T., and Sybertz, E.J.Pharmacology of labetalol in experimental animalsAm. J. Med.75(4A)15-23(1983)