A galanin receptor agonist
货号:ajcx22546
CAS:1217448-19-5
分子式:C40H46N4O6.CF3COOH
分子量：792.9
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Galnon is a galanin (GAL) receptor agonist (K_D= 2.9 µM in Bowes cells expressing GAL₁receptors).¹It inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC₅₀= 10 µM). Galnon (2 mg/kg) reduces the maximal seizure score and increases the latency to first seizure in a mouse model of seizure induced by pentylenetetrazole . It reduces cocaine-induced motor activity and frontal cortex, but not nucleus accumbens, dopamine overflow, as well as blocks cocaine-primed reinstatement of cocaine-seeking behavior in rats.²Galnon (1.5-5 mg/kg) reduces food intake in rats and mice.³

1.Saar, K., Mazarati, A.M., Mahlapuu, R., et al.Anticonvulsant activity of a nonpeptide galanin receptor agonistProc. Natl. Acad. Sci. USA99(10)7136-7141(2002) 2.Ogbonmwan, Y.E., Sciolino, N.R., Groves-Chapman, J.L., et al.The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortexAddict. Biol.20(4)701-713(2015) 3.Abramov, U., FlorÉn, A., Echevarria, D.J., et al.Regulation of feeding by galnonNeuropeptides38(1)55-61(2004)