G6PDi-1 是一种可逆且非竞争性的 6-磷酸葡萄糖脱氢酶 (G6PD) 抑制剂，IC50 为 0.07 μM。
货号:ajcx22540
CAS:2457232-14-1
分子式:C14H12N4OS
分子量：284.3
溶解度:DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml, DMSO: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

G6PDi-1 is a reversible and noncompetitive inhibitor of glucose-6-phosphate dehydrogenase (G6PDH; IC₅₀= 0.07 µM), the enzyme that converts G6P to 6-phosphogluconolactone using NADP⁺as a cofactor in the first step of the pentose phosphate pathway.¹G6PDi-1 (10 and 50 µM) reduces NADPH levels in a variety of cultured cells, including red blood cells and T cells. It decreases colony formation of HCT116 cells when used at concentrations of 20 and 30 µM, an effect that can be rescued by the antioxidant N-acetyl cysteine. G6PDi-1 decreases the production of cytokines induced by phorbol 12-myristate 13-acetate and ionomycin in T cells and prevents PMA-induced oxidative burst in neutrophils.

1.Ghergurovich, J.M., GarcÍa-CaÑaveras, J.C., Wang, J., et al.A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathwayNat. Chem. Biol.16(7)731-739(2020)