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Flibanserin-d4(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flibanserin-d4(hydrochloride)图片
规格:98%
分子量:430.9
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22498
CAS:N/A
分子式:C20H17D4F3N4O.HCl
分子量:430.9
溶解度:DMSO: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Flibanserin-d4is intended for use as an internal standard for the quantification of flibanserin by GC- or LC-MS. Flibanserin is a full agonist of the serotonin 5-HT1Areceptor and an antagonist of 5-HT2A(Kis = 1 and 49 nM, respectively).1It also binds to dopamine D4receptors with Kivalues ranging from 4-24 nM, but demonstrates no affinity for the other 5-HT subtypes or other neurotransmitter receptors.1In vitro, flibanserin has been shown to reduce forskolin-stimulated cAMP formation in cells and rat tissues and to antagonize the accumulation of phosphatidyl inositol turnover induced by 5-HT in the mouse cortex.1At 10 mg/kg, flibanserin can reduce serotonin in the prefrontal cortex and dorsal raphe of conscious rats while increasing extracellular noradrenaline and dopamine.1


1.Invernizzi, R.W., Sacchetti, G., Parini, S., et al.Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: Role of 5-HT1A receptorsBr. J. Pharmacol.139(7)1281-1288(2003)