规格: | 98% |
分子量: | 430.9 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
Background:
Flibanserin-d4is intended for use as an internal standard for the quantification of flibanserin by GC- or LC-MS. Flibanserin is a full agonist of the serotonin 5-HT1Areceptor and an antagonist of 5-HT2A(Kis = 1 and 49 nM, respectively).1It also binds to dopamine D4receptors with Kivalues ranging from 4-24 nM, but demonstrates no affinity for the other 5-HT subtypes or other neurotransmitter receptors.1In vitro, flibanserin has been shown to reduce forskolin-stimulated cAMP formation in cells and rat tissues and to antagonize the accumulation of phosphatidyl inositol turnover induced by 5-HT in the mouse cortex.1At 10 mg/kg, flibanserin can reduce serotonin in the prefrontal cortex and dorsal raphe of conscious rats while increasing extracellular noradrenaline and dopamine.1
1.Invernizzi, R.W., Sacchetti, G., Parini, S., et al.Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: Role of 5-HT1A receptorsBr. J. Pharmacol.139(7)1281-1288(2003)