脱氧胆酸-d4 是氘标记的脱氧胆酸。
货号:ajcx22228
CAS:112076-61-6
分子式:C24H36D4O4
分子量：396.6
溶解度:DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Deoxycholic acid-d₄(DCA-d₄) is intended for use as an internal standard for the quantification of DCA by GC- or LC-MS. DCA is a secondary bile acid that is formedviamicrobial transformation of cholic acid in the colon.¹It can be conjugated to glycine or taurine to produce glycodeoxycholic acid or taurodeoxycholic acid , respectively, in hepatocytes.^1,2,3DCA (0.2% v/v) inhibits spore germination induced by taurocholic acid in sevenC. difficilestrains, as well as inhibits growth and decreases the cytotoxicity ofC. difficileculture supernatants to Vero cells when used at a concentration of 0.02% v/v.¹It inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells when used at a concentration of 200 µM.⁴Fecal and intestinal tissue levels of DCA are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.⁵Increased serum DCA levels have been found in patients with colorectal cancer.⁶

1.Thanissery, R., Winston, J.A., and Theriot, C.M.Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acidsAnaerobe4586-100(2017) 2.Schmid, A., Neumann, H., Karrasch, T., et al.Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS)PLoS One11(2)e0148869(2016) 3.šarenac, T.M., and Mikov, M.Bile acid synthesis: From nature to the chemical modification and synthesis and their applications as drugs and nutrientsFront. Pharmacol.9939(2018) 4.Qiao, D., Gaitonde, S.V., Qi, W., et al.Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradationCarcinogenesis22(6)957-964(2001) 5.Lin, H., An, Y., Tang, H., et al.Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat modelJ. Agric. Food Chem.67(13)3624-3632(2019) 6.BayerdÖrffer, E., Mannes, G.A., Richter, W.O., et al.Increased serum deoxycholic acid levels in men with colorectal adenomasGastroenterology104(1)145-151(1993)