Background:

Bilaid A1 is a tetrapeptide agonist of the µ-opioid receptor (K_i= 750 nM in HEK293 cell membranes expressing the human receptor) and a derivative of bilaid A .¹It inhibits forskolin-induced cAMP accumulation by 47% in HEK293 cells expressing the human µ-opioid receptor when used at a concentration of 10 µM.

1.Dekan, Z., Sianati, S., Yousuf, A., et al.A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptorProc. Natl. Acad. Sci. USA116(44)22353-22358(2019)