您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Atranorin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Atranorin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Atranorin图片
规格:98%
分子量:374.3
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议
10mg电议

产品介绍
Atranorin 是一种地衣次生代谢产物。 Atranorin 通过影响 AP-1、Wnt 和 STAT 信号传导和抑制 RhoGTPase 活性来抑制肺癌细胞运动和肿瘤发生。
货号:ajcx21746
CAS:479-20-9
分子式:C19H18O8
分子量:374.3
溶解度:Chloroform: soluble,DMSO: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Atranorin is a depside lichen metabolite that has been found inS. alpinumand has diverse biological activities.1,2,3,4It is active against the bacteriaB. cereus,B. subtilis,S. aureus,S. faecalis,P. vulgaris,L. monocytogenes, andA. hydrophila(MICs = 1.67, 0.38, 26.7, 13.4, 3.34, 9.83, and 1.67 mM, respectively), the fungiC. albicansandC. glabrata(MIC = 26.7 mM for both), as well as the mycobacteriumM. aurum(MIC = 250 µg/ml).1,2Atranorin is cytotoxic to A270, HL-60, and Jurkat cancer cells (IC50s = 197.9, 93.5, and 181.6 µM, respectively) but not HeLa, MCF-7, SK-BR-3, or HT-29 cancer cells (IC50s = >200 µM).3It inhibits acetic acid-induced writhing in mice when administered orally at doses of 200 and 400 mg/kg.4Atranorin (200 and 400 mg/kg, p.o.) also reduces paw licking and biting in the second, but not first, phase of the formalin test when administered 30 minutes prior to formalin in mice.


1.IngÓlfsdÓttir, K., Chung, G.A., SkÚlason, V.G., et al.Antimycobacterial activity of lichen metabolites in vitroEur. J. Pharm. Sci.6(2)141-144(1998) 2.Yilmaz, M., TÜrk, A.O., Tay, T., et al.The antimicrobial activity of extracts of the lichen Cladonia foliacea and its (-)-usnic acid, atranorin, and fumarprotocetraric acid constituentsZ. Naturforsch. C. J. Biosci.59(3-4)249-254(2004) 3.Ba?korovÁ, M., Ba?kor, M., Mikeš, J., et al.Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acidToxicol. In Vitro25(1)37-44(2011) 4.Melo, M.G.D., AraÚjo, A.A.S., Rocha, C.P.L., et al.Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbiiBiol. Pharm. Bull.31(10)1977-1980(2008)