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Angiotensin II(5-8)(human,rat,mouse)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Angiotensin II(5-8)(human,rat,mouse)(trifluoroacetate salt)图片
包装:1mg
规格:98%
市场价:1182元
分子量:512.6

产品介绍
An endogenous angiotensin II fragment
货号:ajcx21676
CAS:N/A
分子式:C26H36N6O5.XCF3COOH
分子量:512.6
溶解度:Water: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II .1It inhibits renin release from rat kidney slices at a concentration of 50 μM and relaxes rat aorta pre-contracted with phenylephrine .2,1In vivo, microinjection of angiotensin II (5-8) into the ventrolateral periaqueductal gray (vlPAG) of rats increases mean arterial pressure (MAP) and decreases heart rate (HR) by approximately 2.7- and 3-fold less, respectively, than angiotensin II.1It increases the latency to withdrawal in a tail-flick test and the mechanical withdrawal threshold in an incision allodynia test in rats when administered at a dose of 0.2 nmol into the vlPAG. Angiotensin II (5-8) (0.4 nmol, vlPAG microinjection) reduces the number of entries and time spent in the open arms of the elevated plus maze and increases the mean startle amplitude, a measure of conditioned fear, in response to foot shock.3


1.Guethe, L.M., Pelegrini-da-Silva, A., Borelli, K.G., et al.Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioidNeuroscience231315-327(2013) 2.Naftilan, A.J., and Oparil, S.Inhibition of renin release from rat kidney slices by the angiotensinsAm. J. Physiol.235(1)F62-F68(1978) 3.Genaro, K., Juilano, M.A., Prado, W.A., et al.Effects of angiotensin (5-8) microinfusions into the ventrolateral periaqueductal gray on defensive behaviors in ratsBehav. Brain Res.256537-544(2013)