A neuropeptide with diverse biological activities
货号:ajcx21654
CAS:N/A
分子式:C6H8ClN7O.HCl [XH2O]
分子量：266.1
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Amiloride is a potassium-sparing diuretic.^1,2It is an inhibitor of the epithelial sodium channel (ENaC; K_0.5= 2.6 µM for recombinant δENaC expressed inX. laevisoocytes).³It inhibits sodium transport from bovine kidney cortex membrane vesicles with an IC₅₀value of 0.4 µM.⁴Amiloride inhibits the urokinase-type plasminogen activator (u-PA; K_i= 7 µM) and cardiac Na⁺/H⁺-ATPase (IC₅₀= 83.8 µM).^5,6It also inhibits calcium currents mediated by transient receptor potential polycystin 3 (TRPP3; IC₅₀= 143 µM).⁷Amiloride (30 mg/kg) reduces mean arterial pressure in spontaneously hypertensive, but not normotensive, rats.⁸Formulations containing amiloride have been used alone, and in combination with thiazide diuretics, in the treatment of hypertension.

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