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3-hydroxy-3-methylglutaryl-Coenzyme A-d3(ammonium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3-hydroxy-3-methylglutaryl-Coenzyme A-d3(ammonium salt)图片
规格:98%
分子量:982.8
包装与价格:
包装价格(元)
100ug电议
500ug电议
1mg电议
5mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21352
CAS:N/A
分子式:C27H37D3N7O20P3S.4NH4
分子量:982.8
溶解度:Water: 50 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

3-hydroxy-3-methylglutaryl-Coenzyme A-d3is intended for use as an internal standard for the quantification of 3-hydroxy-3-methylglutaryl-coenzyme A by GC- or LC-MS. 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) is an intermediate in several metabolic pathways.1,2,3,4Conversion of HMG-CoA to mevalonate by HMG-CoA reductase is the rate-limiting first step in the cholesterol biosynthetic pathway.3,2Alternatively, HMG-CoA can be cleaved into acetyl-CoA and the ketone body acetoacetate in mitochondria by HMG-CoA lyase.4,1HMG-CoA is also an intermediate in the degradation of leucine.4


1.Laffel, L.Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetesDiabetes Metab. Res. Rev.15(6)412-426(1999) 2.Espenshade, P.J., and Hughes, A.L.Regulation of sterol synthesis in eukaryotesAnnu. Rev. Genet.41401-427(2007) 3.Honda, A., Salen, G., Nguyen, L.B., et al.Regulation of early cholesterol biosynthesis in rat liver: Effects of sterols, bile acids, lovastatin, and BM 15.766 on 3-hydroxy-3-methylglutaryl coenzyme A synthase and acetoacetyl coenzyme A thiolase activitiesHepatology27(1)154-159(1998) 4.Berg, J.M., Tymoczko, J.L., and Stryer, L.Section 25.5 NAD+, FAD, and coenzyme A are formed from ATPBiochemistry5th Edition(2002)