您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > 1,2,3,4-Tetrahydro-β-carboline
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
1,2,3,4-Tetrahydro-β-carboline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1,2,3,4-Tetrahydro-β-carboline图片
规格:98%
分子量:172.2
包装与价格:
包装价格(元)
1g电议
5g电议

产品介绍
A serotonin reuptake inhibitor and metabolite of tryptamine
货号:ajcx20982
CAS:16502-01-5
分子式:C11H12N2
分子量:172.2
溶解度:DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.33 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

1,2,3,4-Tetrahydro-β-carboline is a serotonin reuptake inhibitor (IC50= 7.4 µM in rat brain homogenates) and metabolite of tryptamine .1In vivo, 1,2,3,4-tetrahydro-β-carboline (20 and 40 µg/animal, i.c.v.) reduces serotonin levels in rat forebrain. It induces serotonin-mediated hyperactivity syndrome (HHS) in rats (ED50= 48 mg/kg).21,2,3,4-Tetrahydro-β-carboline (6.25-75 mg/kg) also reduces acetic acid-induced writhing in rats.3


1.Rommelspacher, H., Bade, P., Coper, H., et al.Inhibition of the reuptake of serotonin by tryptolineNaunyn Schmiedebergs Arch. Pharmacol.292(1)93-95(1976) 2.Pannier, L., and Rommelspacher, H.Actions of tetrahydronorharmane (tetrahydro-β-carboline) on 5-hydroxytryptamine and dopamine mediated mechanismsNeuropharmacology20(1)1-8(1981) 3.Rommelspacher, H., Kauffmann, H., Cohnitz, C.H., et al.Pharmacological properties of tetrahydronorharmane (tryptoline)Naunyn Schmiedebergs Arch. Pharmacol.298(2)83-91(1977)