规格: | 98% |
分子量: | 396.9 |
包装 | 价格(元) |
500ug | 电议 |
1mg | 电议 |
Background:
JWH 398 is a synthetic cannabinoid (CB) that activates both central CB1and peripheral CB2receptors (Ki= 2.3 and 2.8 nM, respectively).1It has been reported to be an adulterant of herbal products.2,3(±)-
1.Huffman, J.W.Cannabimimetic indoles, pyrroles, and indenes: Structure-activity relationships and receptor interactionsThe cannabinoid receptors49-95(2009) 2.Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y.Survey of current trends in the abuse of psychotropic substances and plants in JapanLeg. Med. (Tokyo)13(3)109-115(2011) 3.Dresen, S., FerreirÓs, N., PÜtz, M., et al.Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compoundsJournal of Mass Spectrometry45(10)1186-1194(2010) 4.Brents, L.K., Reichard, E.E., Zimmerman, M., et al.Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activityPLoS One6(7)1-9(2011) 5.Brents, L.K., Gallus-Zawala, A., Radominska-Pandya, A., et al.Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retainintermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutralantagonist to partial agonist activityBiochemical Pharmacology83952-961(2012)