Ro 41-0960 是一种选择性儿茶酚-O-甲基转移酶 (COMT) 抑制剂。
货号:ajcx20744
CAS:125628-97-9
分子式:C13H8FNO5
分子量：277.2
溶解度:DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 0.2 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ro 41-0960 is a catechol-O-methyltransferase (COMT) inhibitor.1 It prevents dopaminergic neuron loss induced by L-DOPA in primary rat rostral mesencephalic tegmentum cultures (EC50 = 0.1 μM). Ro 41-0960 (30 mg/kg) potentiates L-DOPA and carbidopa-induced reversal of reserpine-induced akinesias in rats and reserpine-induced catalepsy and hypothermia in mice.2 It reduces striatal 3-methyl-DOPA levels and increases striatal dopamine and 3,4-dihydroxyphenylacetic acid levels in rats. Ro 41-0960 (150 mg/kg) also reduces fibroid volume in the Eker rat model of uterine fibroids.3