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ACTH(1-39)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACTH(1-39)(trifluoroacetate salt)图片
包装:1mg
规格:98%
市场价:3629元
分子量:4541.1

产品介绍
C207H308N56O58S.XCF3COOH
货号:ajcx19292
CAS:N/A
分子式:C207H308N56O58S.XCF3COOH
分子量:4541.1
溶解度:Formic Acid: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

ACTH (1-39) is a potent agonist of melanocortin receptor 2 (MC2R) with an EC50 value of 57 pM in HeLa cells expressing the mouse receptor.1 It induces accumulation of cAMP and release of corticosterone from rat adrenal cells in a concentration-dependent manner.2 ACTH (1-39) also protects neurons from death induced by staurosporine , glutamate, NMDA , AMPA , kainate, quinolinic acid , and reactive oxygen species when used at a concentration of 400 nM.3 Formulations containing ACTH (1-39) have been used in the treatment of systemic lupus erythematosus.

参考文献
1. Kapas, S., Cammas, F.M., Hinson, J.P., et al. Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line. Endocrinology 137(8), 3291-3294 (1996).
2. Bristow, A.F., Gleed, C., FauchÈre, J.L., et al. Effects of ACTH (corticotropin) analogues on steroidogenesis and cyclic AMP in rat adrenocortical cells. Evidence for two different steroidogenically responsive receptors. Biochem J. 186(2), 599-603 (1980).
3. Lisak, R.P., Nedelkoska, L., Bealmear, B., et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp. Neurol. 273, 161-167 (2015).