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Neuromedin N(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Neuromedin N(trifluoroacetate salt)图片
包装:1mg
规格:98%
市场价:1482元
分子量:745.9

产品介绍
Neuromedin N is a neurotensin-like hexapeptide that is synthesized from the same precursor as neurotensin.
货号:ajcx18730
CAS:N/A
分子式:C38H63N7O8•XCF3COOH
分子量:745.9
溶解度:Water: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Neuromedin N is a neurotensin-like hexapeptide that is synthesized from the same precursor as neurotensin. It is highly expressed in the brain but is also expressed in the gastrointestinal system and adrenal glands. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin (IC50s = 16.7 and 3 nM, respectively). Neuromedin N (10 pM) increases the phagocytic function of isolated murine peritoneal macrophages and increases chemotaxis two-fold compared with control, an effect that is blocked by the calcium-channel blocker ryanodine. It induces hypotension in rats and contraction of isolated guinea pig ileum. Neuromedin N (0.05 - 5 μg, i.c.v.) also elicits hypothermia in rats in a dose- and time-dependent manner, which is potentiated by bestatin . Neuromedin N is more potent than neurotensin in stimulating spontaneous motor activity and increasing dopamine metabolism in several brain regions following injection into the rat ventral tegmental area but is less potent than neurotensin when injected into the nucleus accumbens.