您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > MCH(human,mouse,rat)(trifluoroacetate salt)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
MCH(human,mouse,rat)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MCH(human,mouse,rat)(trifluoroacetate salt)图片
包装:1mg
规格:98%
市场价:4593元
分子量:2386.8

产品介绍
Melanin-concentrating hormone (MCH) is an endogenous hypothalamic neuropeptide hormone that is an agonist at MCH receptors.
货号:ajcx18660
CAS:N/A
分子式:C105H160N30O26S4•XCF3COOH
分子量:2386.8
溶解度:Water: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Melanin-concentrating hormone (MCH) is an endogenous hypothalamic neuropeptide hormone that is an agonist at MCH receptors. It binds to MCH1 and MCH2 receptors (IC50s = 0.17 and 2.9 nM, respectively, for the human receptors) and stimulates calcium accumulation with EC50 values of 28 and 50 nM, respectively, in an aequorin bioluminescence functional assay. MCH also binds to the rat MCH1 receptor (Ki = 0.16 nM in CHO cells), stimulates calcium accumulation (EC50 = 1.79 nM), and inhibits intracellular cAMP accumulation induced by forskolin . It binds to mouse MCH receptors on melanoma B16 cells (Ki = 33 nM) and dose-dependently activates the mitogen-activated protein kinase (MAPK) signaling pathway. MCH (5 nmol/kg, i.c.v.) increases cumulative food intake in rats.